Vulvodynia inflammation resolution

VULVODYNIA

Localized provoked vulvodynia (LPV) is a chronic condition impacting more than one in ten women at some point in their lives. It results in severe vulvar pain and often leads to additional health issues, such as depression, anxiety and fertility problems. Given the prevalent nature of the condition and lack of adequate treatment available on the market, we embraced the challenge of utilizing the unique properties of maresins to aid in the resolution of vulvodynia inflammation.

With robust preclinical science demonstrating the role of maresins in relieving vulvodynia-related pain and inflammation, we are now in the process of conducting clinical trials to develop an efficacious and highly-targeted maresin-based treatment for LPV.

Vulvodynia in numbers: a call for action

Prevalent

Women suffering from vulvodynia at any point in time1, across all ages, with lifetime prevalence up to 16%

Costly

Estimated annual cost of vulvodynia in the US2

Hophazard

Number of treatment modelites attempted based on survey of 344 woman with vulvodynia (steroids, hormone therapy, anticonvulsants, antidepressants, psychotherapy, NSAIDs, physiotherapy, acupuncture, surgery, etc.)3

Ineffective

Women with vulvodynia who see no improvement after six years of treatment, despite current multimodal approach4

Ignored

No treatment approved by FDA for vulvodynia
References

From lab bench to clinical trials – and beyond

Our mission to develop a disruptive treatment for LPV is making significant progress, with several important milestones already achieved.

1

Demonstrated significant efficacy of MaR1-derived compound (MaR102) in animal models

2

Demonstrated safety of MaR102 in various animals species and with different administration modes

3

Finished development of GMP-compliant manufacturing process for MaR102 drug substance and formulation

4

Successfully conducted Pre-Investigational New Drug (IND) meeting with the Food and Drug Administration (FDA)

5

Completed the preparation for our first clinical trial: a Phase 1/2a study of topical MaR102 in women with LPV to demonstrate both product safety and efficacy

Leaders in targeting inflammation and pain at the source