Discover a new era in effective pain relief with maresin compounds
Maresin compounds are critical components of the inflammation resolution machinery, meaning their benefits are not limited to a single disease. Their therapeutic potential extends to many indications involving unresolved inflammation and chronic pain. Our mission is to expand and enhance treatment options for patients suffering from conditions, including:
As part of their inflammation resolution machinery, maresin compounds promote the clearance of dead cells – a process known as efferocytosis. This suggests that maresin compounds could potentially offer benefits for diseases characterized by a failure to remove dead cells, such as autoimmune disease like systemic lupus erythematosus (SLE).1 To explore this further, we are currently developing a MaR1 analog as an injectable treatment for SLE.
1 Navarini L, Bisogno T, Margiotta DPE, et al. (2018) Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results. J Immunol Res. 2018:5264195.
Evidence suggests that MaR1 can control inflammation and promote tissue repair in skin conditions such as vitiligo, psoriasis and atopic dermatitis. Recognizing this promising therapeutic potential, we are leveraging our MaR102 topical formulation to conduct an accelerated development program for inflammatory skin conditions, partially based on preclinical data generated during the vulvodynia trial.
2 Cezar TLC, Martinez RM, Rocha CD, et al. (2019) Treatment with maresin 1, a docosahexaenoic acid-derived pro-resolution lipid, protects skin from inflammation and oxidative stress caused by UVB irradiation. Sci Rep. 9(1):3062.
Given that inflammation is a hallmark of cancer, we are curious about whether maresin compounds could become a novel solution to support cancer treatment through inflammation resolution. That’s why we are preparing to investigate this exciting possibility in the future.
At SPM Therapeutics, we are not just following the science – we're driving it forward. Pushing the boundaries of what is possible in high-performing pain relief and actively redefining standards across the therapeutics landscape.
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3 Kipper, F.C., Deng, J., Rothenberger, E., Kelly, A., Duncan, M., Huang, S., Serhan, C.N., Panigrahy, D. (2022) Maresins prevent breast cancer dormancy escape via resolution of inflammation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res;82(12_Suppl):Abstract nr 1329. Available at: Abstract 1329: Maresins prevent breast cancer dormancy escape via resolution of inflammation | Cancer Research | American Association for Cancer Research (aacrjournals.org)